Viccillin-SX 1500 Dosage/Direction for Use

Viccillin-SX 1500 powder for injection can be administered by either IV or IM routes. The following dilutions may be used (see Table 1).


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Usual Dose Range: 1.5-12 g/day in divided doses every 6 or 8 hrs up to a maximum daily dosage of sulbactam 4 g. Less severe infections may be treated on a 12-hr interval schedule. (See Table 2.)


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Dosage: Children, Infants and Neonates: 150 mg/kg/day (corresponding to sulbactam 50 mg/kg/day and ampicillin 100 mg/kg/day) every 6 or 8 hrs in accordance with the usual practice for ampicillin. In neonates during the 1st week of life (especially pre-terms), dosing is usually every 12 hrs. More or less frequent dosing may be indicated depending on the severity of the illness and the renal function of the patient. Treatment is usually continued until 48 hrs after pyrexia and other abnormal signs have resolved. Treatment is normally given for 5-14 days but the treatment period may be extended or additional ampicillin may be administered in severely ill cases.
Patients with Severe Impairment of Renal Function (creatinine clearance <30 mL/min): The elimination kinetics of sulbactam and ampicillin are similarly affected and hence the plasma ratio of one to the other will remain constant. The dose of Viccillin-SX 1500 powder for injection in such patients should be administered less frequently in accordance with the usual practice of ampicillin. In treating patients on restricted sodium intake, it should be noted that 1500 mg of Viccillin-SX 1500 powder for injection contains approximately 115 mg (5 mmol) of sodium.
Prophylaxis of Surgical Infections: 1.5-3 g of Viccillin-SX 1500 powder for injection should be given at induction of anesthesia, which allows sufficient time to achieve effective serum and tissue concentrations during the procedure. The dose may be repeated 6-8 hrly; administration is usually stopped 24 hrs after the majority of surgical procedures, unless a therapeutic course of Viccillin-SX 1500 powder for injection is indicated.
Administration: For IV administration, Viccillin-SX 1500 powder for injection should be reconstituted with sterile water for injection or any compatible solution and allowed to stand to allow any foaming to dissipate to permit visual inspection for complete dissolution. The dose can be given by bolus injection over a minimum of 3 min or can be used in greater dilutions either as a bolus or as an IV infusion over 15-30 min. Meiji ampicillin sodium/sulbactam sodium parenteral may also be administered by deep IM injection. If pain is experienced, 0.5% sterile solution for injection of anhydrous lignocaine HCl may be used for reconstitution of the powder.